A dust-up
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Meaning
A fight.
Origin
Clearly this term alludes to the dust raised in a scuffle or fight. It isn't an especially old phrase and first appears around the end of the 19th century. The earliest printed reference I can find is Sidney L. Hinde's The fall of the Congo Arabs, 1897:
"An American nigger said ... they ain't had such a dust-up in this hole since creation."

