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The meaning and origin of the expression: At one's wits' end

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At one's wits' end

What's the meaning of the phrase 'At his wits' end'?

Perplexed; unable to think what to do.

What's the origin of the phrase 'At his wits' end'?

From the Bible, Psalms 107:27 (King James Version):

They reel to and fro, and stagger like a drunken man, and are at their wits' end.

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